Topamax and Weight Loss

Topamax is an anti-seizure medication that helps reduce the number of seizure attacks and reduce or prevent migraines. It also has been shown to work for weight loss. However, it also has many negative effects that can impact on your health.

Topamax is sold as an anti-seizure medication in patients at least 2 years of age. This can be used to help reduce the number of seizure attacks that the patient experiences as well as reducing or preventing migraines. This medication cannot be used to stop seizures or headaches that have already begun.

Topamax and Weight Loss

While it has not been approved for this purpose, Topamax has been shown to assist with weight loss. A number of conditions have been theorized as to why Topamax contributes to this condition.

  • Change Taste Sensation- A side effect of Topamax causes a reduction in the production of saliva. This can reduce taste sensation, depriving patients of some of the pleasure associated with eating. This can help patients avoid overeating that can lead to weight gain.
  • Reduce Cortisol- Topamax may also cut down on the body's production of cortisol, a stress hormone that increases the production of insulin. This can reduce food cravings and appetite, which also helps patients prevent overeating or eating rich, dense foods.
  • Impact on Blood Glucose and Insulin Secretion- Topamax has been shown to reduce insulin secreting and helping the body to manage the blood glucose level more effectively. This can allow patients to ingest stored fat as an energy source rather than focusing on taking in additional carbohydrates to maintain energy levels. This means patients will feel less hungry and burn weight more effectively.
  • Act on Addition Centers of the Brain- Topamax may dull the function of addition centers in the brain. This can help patients limit their desire to partake in substances such as tobacco or alcohol. It can also limit the patient's desire to eat addicting foods such as junk food or desserts.


Topamax can cause impaired thinking or blurred vision. Patients should avoid driving or performing any activities that demand their full attention until they are aware of how this medication will affect them. Patients should avoid drinking alcohol while using Topamax as this can increase your risk of developing these side effects.

Topamax may also increase your risk of developing kidney stones. Any diets that increase your intake of salt or other risk factors that could contribute to the development of kidney stones should be avoided while using this medication. This includes "ketosis" diets that are high in fat and promote a low intake of carbohydrates.


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