Metastatic Liver Cancer

Metastatic liver cancer occurs because of the spreading of a primary cancer to the liver. Although incurable, there are a number of treatment options available for metastatic liver cancer.

When the cancer cells start breaking away from the main cancer location, they enter into the bloodstream and get dispatched to everywhere in the body. Spreading of the cancer to the liver is caused because filtering of the blood coming from all over the body takes place in it. It has often been seen that the diagnosis of a certain cancer in a person is made only after metastatic liver cancer has been discovered in him. It is thus important to understand this type of cancer so that one is able to diagnose it at an earlier stage. 

What Is Metastatic Liver Cancer?

Liver metastasis is the name given to a cancerous tumor that has reached the liver from somewhere else in the body. Another name for this type of cancer is secondary liver cancer as it had not originated in the liver which is the case in primary liver cancer. Primary liver cancer is very rare and most cases of liver cancer are of the secondary kind.

A metastatic liver tumor does not contain genuine liver cells. It is made up of cancer cells that belong to that organ of the body from where the primary cancer spread. These organs might include the lungs, colon or a cancerous breast.

This condition is also known by the name of:

  • Liver metastases
  • Metastatic liver cancer
  • Metastases to the liver

What Causes Metastatic Liver Cancer?

Cancer present in any part of the body can spread to the liver. Cancers that have the tendency to spread to the liver are:

  • Colorectal cancer
  • Pancreatic cancer
  • Breast cancer
  • Lung cancer
  • Stomach cancer
  • Melanoma
  • Esophageal cancer

The site or location of the primary cancer determines the chances of spreading of the cancer to the liver. Metastatic liver cancermay surface a long while after the removal of the primary cancer. However, there is also the possibility that when diagnosis of the primary cancer is made, the cancer might have already metastasized to the liver.

Metastatic Liver Cancer Symptoms

In the early stage of the condition, liver metastasis does not show any kind of symptoms. However, as the cancer spreads, swelling of the liver occurs. At this point, the occurrence of the following symptoms becomes highly likely:

  • Appetite loss
  • Loss of weight
  • Urine of a dark color
  • Bloating or swelling of the abdomen
  • Jaundice, characterized by the yellowing of the whites of the eyes or the skin
  • Right shoulder pain
  • Upper right abdomen pain
  • Nausea
  • Confusion
  • Fever and excessive perspiration
  • Formation of a lump below the ribcage on the right side of the abdomen

Seeing the doctor becomes necessary if you start noticing the following symptoms.

  • Excessive vomiting
  • Blood in vomit
  • A sudden and unexpected loss in weight
  • Black stools
  • Swallowing problems

Experiencing symptoms of metastatic liver cancer warrants an immediate consultation with your doctor. If you had been diagnosed with cancer earlier in your life then you must keep on seeing your doctors regularly. 

Metastatic Liver Cancer Diagnosis

Diagnosing metastatic liver cancer is not that easy for the doctors because it hardly shows any symptoms in its earlier stages. However, the doctor might suspect is presence in patients who have suddenly lost a good amount of weight or have had suffered a cancer that has been known to metastasize to the liver. Blood tests to check the functioning of the liver are the first means used by doctors for diagnosing liver cancer. Since the tests are not able to clearly confirm a cancer diagnosis, imaging tests like CT and MRI are used to detect the tumors. However, a liver biopsy is by far the best means for diagnosing liver cancer.  

Metastatic Liver Cancer Treatments

Even though there is no cure available for liver cancer, there are treatment options available that can provide relief to the patient from the symptoms and enhance his life expectancy. American Cancer Society states that approximately 15% of the patients diagnosed with liver cancer have a life expectancy of about five years (ACS, 2012).   

Cases of liver metastases can be treated using a number of options these days. The treatment method for this type of cancer is chosen on the basis of:

  • The overall health and age of the patient
  • The number, size and location of the metastatic tumors
  • Primary cancer’s location
  • The cancer treatments that the patient has received till then

Systemic Therapies

There are systemic cancer therapies also available for patients of secondary liver cancer in which treatment of the whole body is done via the bloodstream. Some of these therapies are: 

Therapies

Description

Chemotherapy

A treatment method in which the cancer cells are killed through the use of drugs.

Biological response modifier (BRM) therapy

This treatment method involves the use of vaccines, certain antibodies and growth factors as they have the capability to enhance the abilities of the immune system and can help in fighting the cancer. BRM therapy usually lessens the side effects caused by other therapies used for cancer treatment.  

Targeted therapy

This therapy makes use of both drugs and monoclonal antibodies which are prepared in a laboratory. These antibodies have been designed to cling to cancer cells. The main idea behind this treatment method is to identify the cancer cells and thus improve the targeted removal of the cancer cells through radiation, drugs and blockade of cancer cell growth. Targeted therapy usually has a lot less risks than other treatments. 

Hormonal therapy

This therapy involves the removal, blockage or addition of certain hormones. When used for cancer treatment, this therapy focuses on stopping or slowing down the growth of cancerous tumors that form in the prostate or the breast.

Localized Therapies

The tumor cells and the tissues surrounding them are targeted in the localized therapies. This type of treatment is beneficial only if the diagnosis of the cancer is made at an earlier stage.

Radiation therapyis used to shrink the tumors and kill the cancer cells by making use of high-energy radiation. The radiation used might come from:

  • Radiation machines in which case the process is called external beam radiation
  • Radioactive materials that have been placed in the body near the cancer cells in which case the process is called internal radiation
  • Radioactive substances that are capable of moving throughout the bloodstream

Surgical removalis a treatment method that can be used for removing tumors that are small in size and number and are located in a small region of the liver.

Long-Term Outlook for Metastatic Liver Cancer

The location where the primary cancer is present and the extent to which the cancer has metastasized in the liver decide whether the treatment would be successful or not.

Research is ongoing to find new treatment methods that can help in the removal of the cancer cells. The treatment method which is currently being researched is hyper stimulation of the immune system and disruption of the steps that lead up to liver metastasis. 

Recommended:

Liver Cancer Survival Rate

Liver cancer is a serious disease that can be primary or secondary. Liver cancer survival rates and treatments will vary depending on the stage of cancer and other factors.


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